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Contrôle et Immunologie des Maladies Entériques du Nouveau-né - UR 1282
(ACR)
- Mot(s) clé(s) :
Objet d'étude : cryptosporidium parvum, dendritic cell, eimeria, epithelial cell, natural killer cell, neonates, parasite animal
Question sociétale et finalité, contexte : santé animale, santé humaine
Démarche, discipline : cell biology, Health, Immunité innée, Immunology, immunothérapie, Molecular biology, Parasitology
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Objet d'étude : cryptosporidium parvum, dendritic cell, eimeria, epithelial cell, natural killer cell, neonates, parasite animal
Question sociétale et finalité, contexte : santé animale, santé humaine
Démarche, discipline : cell biology, Health, Immunité innée, Immunology, immunothérapie, Molecular biology, Parasitology
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- Description détaillée :
Research team CIMEN work on diseases caused by enteric protozoa which strongly affect livestock Afficher la suite
Research team CIMEN work on diseases caused by enteric protozoa which strongly affect livestock production. These last years, our researches focused on various components of the innate immune response of neonates and their peculiarites to better control cryptosporidiosis. In addition to our work on the mucosal response to infection, we developed an immunostimulation strategy based on Toll-like receptor stimulation that led to a rapid control of Cryptosporidium parvum development. We demonstrated and deciphered the preferential Th1-type cytokine response to TLR ligands in the intestine and associated lymphoid tissues in neonates (mouse model, lambs). In ruminants, we studied the phenotypic and functional specificities of blood neonatal NK cell and described for the first time this population in sheep opening the way for further studies in the intestine of neonates infected by C. parvum.

Keywords: mucosal immunology, neonatal immunity, innate immunity, protozoan parasite.

Ongoing research project :
The research project of CIMEN team is investigating the induction of intestinal innate immune responses in neonates. Cryptosporidium parvum parasite development being restricted to the intestinal epithelium, this elegant model of infection will be used to study the initiation of immune responses in mouse and lambs. The project will focus on the crosstalk between the tripod enterocyte, dendritic cells (DC) and innate lymphocytes. We plan to decipher (i) the molecular mechanisms by which epithelial cells respond to the parasite with a specific focus on pattern recognition receptors and inflamasome triggering; (ii) the role of the conventional and plasmacytoid DC on the direct control of the parasite development or by activating innate lymphocytes and to characterize (iii) the different subsets of NK cells and their functional properties in the neonatal intestine.
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